منابع مشابه
Microbial Host Engineering: beyond the Metabolic Pathway
As the focus of microbial metabolic engineering shifts to include bulk commodities, two aspects of this research have become increasingly important. One is the requirement for high production titers in order to make the process economically viable. The second is to engineer microbes that are tolerant to these target products, many of which are toxic to cell growth. This review focuses on recent...
متن کاملPune University Metabolic Pathway Engineering ( PuMPE ) Resource
PuMPE is a comprehensive resource that provides integrated information on metabolome of bacterial systems. The genome data is annotated to infer metabolic pathways using in-house tools and web-based sources. PuMPE introduces a novel aspect of metabolic categorization. It is the first resource to provide metabolome-based tree computed by comparing metabolome between bacteria. PuMPE has metabolic...
متن کاملRemodeling bacterial polysaccharides by metabolic pathway engineering.
Introducing structural modifications into biomolecules represents a powerful approach to dissect their functions and roles in biological processes. Bacterial polysaccharides, despite their rich structural information and essential roles in bacterium-host interactions and bacterial virulence, have largely been unexplored for in vivo structural modifications. In this study, we demonstrate the inc...
متن کاملMetabolic engineering of cottonseed oil biosynthesis pathway via RNA interference
Cottonseed oil is recognized as an important oil in food industry for its unique characters: low flavor reversion and the high level of antioxidants (VitaminE) as well as unsaturated fatty acid. However, the cottonseed oil content of cultivated cotton (Gossypium hirsutum) is only around 20%. In this study, we modified the accumulation of oils by the down-regulation of phosphoenolpyruvate carbox...
متن کاملEngineering of a xylose metabolic pathway in Rhodococcus strains.
The two metabolically versatile actinobacteria Rhodococcus opacus PD630 and R. jostii RHA1 can efficiently convert diverse organic substrates into neutral lipids mainly consisting of triacylglycerol (TAG), the precursor of energy-rich hydrocarbon. Neither, however, is able to utilize xylose, the important component present in lignocellulosic biomass, as the carbon source for growth and lipid ac...
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ژورنال
عنوان ژورنال: Synthetic and Systems Biotechnology
سال: 2018
ISSN: 2405-805X
DOI: 10.1016/j.synbio.2018.01.002